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看了許多天然硅藻土吸水皂墊 矽藻土 杯墊 吸水墊 文章、開箱、評價、心得分享等資訊後,

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印地安人與藍鳥之戰,印地安人靠著Mike Napoli(拿坡里)的二壘安打加上陽春砲、打回2分打點,5局結束與藍鳥戰成2:2平手。

1局上Napoli就有所發揮,一壘有人時敲出深遠二壘安打,幫助印地安人先馳得點。

原先手指就有受傷的印地安人先發投手Trevor Bauer,1局下在只投0.2局的情況下,就因手指傷口裂開、血流不止退場,留下一、二壘有人的危機,可惜藍鳥沒能把握機會,沒有攻下分數。2局下藍鳥靠著Michael Saunders轟出陽春砲,追平比分。

4局下又是Napoli發威,再度棒打藍鳥先發投手Marcus Stroman,轟出中外野方向陽春砲,印地安人取得2:1領先。5局下藍鳥展開反攻,Ezequiel Carrera無人出局敲出三壘安打,隨後靠著Ryan Goins的內野滾地球,藍鳥再度扳平比數,5局結束雙方戰成2:2平手。

★更多相關新聞

道奇第4戰 將推大聯盟史上最菜季後賽先發投手
擊破防禦率王 道奇老將岡薩雷茲開轟
印地安人牛棚安穩 再勝藍鳥聽牌
Bauer血濺球場 投不滿1局提前退場
桑切斯打太好 麥肯萌生不如歸去之意

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If you don't like baseball, watch baseball, or know what baseball is, know this — the 2016 World Series is different.?

When the Cleveland Indians host the Chicago Cubs in a best-of-seven series

... 較多If you don't like baseball, watch baseball, or know what baseball is, know this — the 2016 World Series is different.?

When the Cleveland Indians host the Chicago Cubs in a best-of-seven series beginning Tuesday night, we won't just witness another run-of-the-mill Fall Classic. This year's matchup is steeped in history, characterized by decades of suffering, and features two teams who know a whole lot about losing.?

By the end of this World Series, one city will hoist the championship trophy for the first time in a very, very, long time.?

SEE ALSO: The dark side of a feel-good World Series

The Cubs haven't won a World Series since 1908, the longest championship drought in North American professional sports. They haven't even been to a World Series since 1945.?

Chicago's franchise is supposedly cursed, and the years of bad luck and losing seasons prove it.?

But a revamped front office and minor-league farm system have turned the Cubs from lovable losers to a national powerhouse. They showed up at Spring Training with the best odds of winning the World Series and led baseball with 103 wins during the regular season. ?

It's easy to root for this year's Cubs, until you remember who's in the other corner.

Image: Jamie Squire/Getty Images

The Indians haven't won a World Series since 1948, the second longest championship drought in baseball. Cleveland stumbled through the 1970s and '80s, failing to make the postseason every season in a 24-year span. Its last World Series appearances — both losses, of course — came in 1995 and 1997.?

The history of this World Series is huge, and each team's drought will be hyped constantly. But there's more to this matchup.

So, if you're just tuning in, here are our five biggest storylines to watch during the 112th World Series.?

1. Battle of the bullpens



The Cubs and Indians have one very specific thing in common —?in July, they both picked up two of the best relief pitchers in baseball, courtesy of the New York Yankees. The Indians, who traded for Andrew Miller, and the Cubs, who traded for Aroldis Chapman, understood the value of a shut-down bullpen in the postseason, and made sure to stock up on elite relievers.?

Andrew Miller has been unbeatable.

Image: Elsa/Getty Images

The results have been undeniable.?

Miller struck out 21 batters in 11.2 scoreless postseason innings for the Indians, earning MVP honors in the American League Championship Series. He's at the helm of a monster bullpen with a 1.67 ERA in the playoffs.?

Cleveland's strategy this postseason is simple —?get an early lead and let the bullpen save it.?

Though the Cubs' bullpen might not have the flashiest postseason numbers this year — a 3.53 ERA and a couple blown saves — it still features Chapman, who fires 100-mph fastballs right by hitters on a regular basis.?



Image: mlb

Keep an eye on the bullpen. This series could hinge on the guys emerging from it.?

2. The fountain of youth



You can bet Fox announcers will constantly tout the young talent of both World Series teams, particularly Chicago.?

The average age of the Cubs infield — featuring All-Star Addison Russell, NLCS co-MVP Javier Baez, 2015 Rookie of the Year Kris Bryant and MVP candidate Anthony Rizzo — is 24 years old.?

Russell and Baez are only 22 and 23, respectively. They epitomize the Cubs' philosophy of developing young superstars and complimenting them with big-budget free agent signings.?

Clearly, that model has worked.?

Javier Baez was the Cubs' co-MVP of the NLCS.

Image: mlb

The Indians have shallower pockets, and couldn't afford to take the powerhouse approach. Instead, Cleveland relies on contributions from more frugal pick-ups like Rajai Davis and Mike Napoli.?

They still boast a solid young core that features All-Star shortstop Francisco Lindor (22), José Ramirez (24) and rookie Tyler Naquin (25). Rookie starting pitcher Ryan Merritt (24) made only one major league start before helping the Indians clinch a World Series berth last week.?

For a World Series soaked in historical context, this Fall Classic belongs to the kids.?

3. It starts with starting pitching



With all eyes on the bullpen, starting pitching could be the Cubs' not-so -secret weapon.?

Chicago boasts a deep starting rotation that led the majors with a 2.96 ERA during the regular season. Between Jon Lester — who's posted a 0.86 ERA in three postseason games — Jake Arrieta and Kyle Hendricks, the Cubs are set.?

The Indians had a brilliant starting rotation of their own at one point this season, but lost two of their talented arms to injury. There are murmurs of one of them returning, but more on that later.

Aside from Game 1 starter and former Cy Young Award winner Corey Kluber, the Indians have relied on good — but not elite — starting pitchers who turn in gutsy performances.?

Corey Kluber won 18 games in 2016.

Image: Maddie Meyer/Getty Images

Josh Tomlin is largely untested. Trevor Bauer bled himself off the mound last week. Ryan Merritt has two major league starts to his name.

Still, the Indians starting rotation has an impressive 1.86 ERA this postseason.

But don't let the numbers fool you. Chicago has an edge here.?

4. Comeback kids



This World Series will feature elite relief pitching, the best of the best. Games will surely come down to the late innings.

But here's something to chew on.?

This postseason, the Cubs have scored 17 runs in the seventh inning or later, the best of any team. They've thrived on comeback wins, and never seem to go down quietly.

Image: Jamie Squire/Getty Images

How many have the Indians scored in the seventh or later?

Zero.?

Cleveland appears incapable of putting runs on the board with their backs against the wall. Their game plan, as mentioned, is to get an early lead and turn things over to the bullpen.

That might not work against a team like the Cubs.?

Chicago's bullpen is beatable, but it's still formidable in the late innings, a time when the Indians' bats seem to be incredibly weak.?

5. Reviving the dead



Chicago won more than 100 games without Kyle Schwarber, one of the Cub's elite young superstars. Schwarber hit five postseason home runs last year, but tore his ACL just two games into this season.?



Now, there's talk he might be back.?

Since coming off the disabled list on Saturday, Schwarber has been getting back into playing shape in the Arizona Fall League (AFL). Depending on his performance in an AFL game Monday night, the Cubs could activate him for a designated hitter role in the World Series on Tuesday.?

There's sure to be rust, but if Schwarber performs anything like the player he was in 2015, he could be a difference-maker.?

For Cleveland, it's looking like starting pitcher Danny Salazar will return as well.

The All-Star right-hander, who struck out more than 10 batters per nine innings during the regular season, has been sidelined with a forearm strain since Sept. 9. It's unclear whether or not Salazar will start, considering the long layover, but he would bring stability to a starting rotation that desperately needs it.?

Both teams aren't taking any chances. They want their best lineups on the field.

Image: Maddie Meyer/Getty Images

This World Series figures to be epic, not only because of the historical context, but because of how each team's strengths counter the other's. Chicago's bats are scary, but Cleveland's pitching is hot. The Indians' bullpen is ferocious, but the Cubs know how to score late.?

Regardless, one of these long-suffering franchises will see relief soon. A historic championship drought will be quenched with a champagne shower.?

The loser? Well, they're already used to losing, and can wait just a little longer.?

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2016年10月25日週二 台北標準時間上午6時37分





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下面附上一則新聞讓大家了解時事

工商時報【杜蕙蓉╱台北報導】

中裕新藥(4147)昨(30)日公告,該公司於美國時間10月29日在紐奧良舉行IDWeek 2016感染性疾病研討會中口頭報告,TMB-301臨床試驗主要指標(primary endpoint)的結果,證明該新藥能夠有效降低病毒量,可提具多重抗藥性的愛滋病人一個全新的治療藥物。

根據報告,針對抗病毒治療失敗的愛滋病患,在接受起始劑量2000mg TMB-355(ibalizumab)靜脈注射後病毒量有顯著降低。

中裕公告指出,此次臨床試驗收案40人,試驗的頭7天(0-7天)為控制期,病患於第7天注射起始劑量,給予起始劑量7天後(第14天),與基線(第7天)相比83%的病患病毒量下降大於0.5 log10,相較之下僅有3%的病患於控制期(0-7天)病毒量下降大於0.5 log10,以上結果具有統計意義(p<0.0001)。

從7-14天,60%的病患病毒量下降大於1.0 log10(p<0.0001),平均病毒下降量為1.1 log10 (p<0.0001),在這期間沒有與治療相關的嚴重不良反應或藥物停用。

85%以上的受試病患至少有一個對核甘酸反轉錄鋂抑制劑(NRTI)、非核甘酸反轉錄鋂抑制劑(NNRTI)或蛋白鋂抑制劑(PI)有抗藥性的突變,60%以上的病患至少有一個對嵌入鋂抑制劑(INI)有抗藥性的突變,受試病患對平均75%以上的NRTI、NNRTI及PI類藥物及1-2個INI藥物有抗藥性,50%的病患對至少三類抗愛滋病毒藥物的所有藥物有抗藥性。

中裕表示,從臨床數據證明,TMB-355能提供這些具多重抗藥性的愛滋病人一個全新的治療藥物。

Jacob Lalezari醫師(eStudySite分部-Quest臨床試驗中心醫學總監)說,如果獲FDA核准,ibalizumab將會是第一個針對具有高度抗藥性愛滋病患有效的長效型生技藥品,此試驗顯示ibalizumab併用其他藥物可提供急需新藥的病患一個新的治療方式,並且有可能改變未來愛滋病治療趨勢。

ibalizumab已獲得美國FDA的”突破性療法”資格認定,先前則已獲FDA的”孤兒藥”資格認定。此次臨床三期試驗是申請生技藥品許可證(BLA)所需的最後一個樞紐試驗,已於2016年10月24日結束,其24周治療期間的安全性及次要藥效評估指標將於近期公布。

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